Transcriptome sequencing revealed the inhibitory mechanism of ketoconazole on clinical Microsporum canis
نویسندگان
چکیده
منابع مشابه
Dermatophytosis, Microsporum canis, Trichophyton mentagrophytes, Microsporum gypseum
Overview: The fungal skin disease dermatophytosis has come to be called ringworm because of the appearance of the skin lesion that characteristically occurs with this disorder: a circular area of hair loss with a red, raised outer rim. These lesions result from an inflammatory reaction to the fungus. Most often, dogs and cats are infected by the Microsporum canis fungus, but other types of fung...
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Background: Mammalian preimplantation development is a complex process involving dramatic changes in the transcriptional architecture. However, it is still unclear about the crucial transcriptional network and key hub genes that regulate the proceeding of preimplantation embryos. Materials and Methods: Through single-cell RNAsequencing (RNA-seq) of both human and mouse preimplantation embryos, ...
متن کاملCarbohydrate metabolism in Microsporum canis.
Enzyme systems concerned in the breakdown of carbohydrates by dennatophytes have been little studied, the principal contribution being a study of a number of enzymes of the glycolytic and hexosemonophosphate pathways and of the tricarboxylic acid cycle in cell-free extracts of Trichophyton mentagrophytes (Jensen, Altschuller & Bard, 1957). The effect of different substrates and pH values on the...
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Dermatomycoses caused by Microsporum canis are frequent in domestic animals and easily transmissible to humans. Several proteases secreted by this fungus were identified as potential virulence factors, but the construction of deficient strains is required to investigate their role in the pathogenesis of the disease. Using target genes encoding two of these proteases, a first evaluation of the u...
متن کاملIn Vitro Comparison of MIC Crude Extracts of Active Actinomycetes Isolated with Terbinafine, Griseofulvin Ketoconazole and Fluconazole against Microsporum Canis, Microsporum Gypseum and Trichophyton Mentagrophytes
Abstract Background and Objective: Dermatophytes are the fungi that have the ability to attack the keratinized tissues such as the skin, hair and nails. Infections caused by these organisms are named dermatophytosis. We aimed to compare Minimum inhibitory concentration (MIC) of Crude extracts of Active Actinomycete Isolates with Terbinafine, Griseofulvin, Ketoconazole and Fluconazole Drugs ...
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ژورنال
عنوان ژورنال: Journal of Veterinary Science
سال: 2021
ISSN: 1229-845X,1976-555X
DOI: 10.4142/jvs.2021.22.e4